Topic: paraventricular hypothalamic nucleus

Paradoxical sleep has been named because it is a state paradoxically close to wakefulness (W) at the cortical level. In this context, our research group has shown using cFos mapping that only a few limbic cortical structures contain activated neurons during PS in contrast with W during which most of the cortical structures are activated. In the present study, we directly determine whether the same or different neurons are activated during W and PS using a new genetic approach. We mapped the neurons activated during W and PS in the transgenic TRAP2-red mouse model. Four male mice implanted wit

The subjective experience of internal sensation processing (interoception) which affects emotions, appears to be altered in autism spectrum disorder (ASD) and anxiety disorders. Anxiety is a frequently co-occurring condition in patients with ASD, exacerbating ASD symptoms and causing functional impairments in these individuals. In contrast to anxiety in normotypic populations, our knowledge about the neuronal correlates of anxiety in ASD is very limited. Here we investigated behavioral responses to CO2 inhalation in Setd5 haploinsufficient (Setd5+/-) mice, which demonstrate signs of ASD and al