Topic: parvalbumin positive interneurons

The hippocampal dentate gyrus (DG) to CA3 pathway plays a key role in encoding new experiences that are ultimately consolidated in the anterior cingulate cortex (ACC). Experience-dependent changes among excitatory neurons in the DG ‒ CA3 circuit have been intensely studied. However, DG cell axons innervate not only CA3 pyramidal neurons but also inhibitory, parvalbumin positive interneurons (PV IN) to provide strong feed-forward inhibition (FFI) onto CA3 pyramidal neurons. Following learning, FFI onto CA3 is temporarily increased which may be a key element for consolidation and long-term memor

Increasing evidence have highlighted significant sex-related differences in animal physiology and behavior, both in health and disease. Despite that, most neuroscience research involving animal models is still conducted using males only. Estrogen (E2) is known to have a protective role in females, mainly by preventing inflammation, however, when hormone levels decline, females become more prone than males to metabolic, cardiovascular and psychiatric diseases. Thanks to our established conditional knockout mouse model (Npy1rrfb mice), in which the gene encoding for the main NPY receptor Y1 is s

Aims: L-DOPA-induced dyskinesias (LID) cause disability in Parkinson’s disease patients undergoing L-DOPA treatment. It is known that maladaptive plastic changes in both pre-and post-synaptic components of striatal network contribute to LID. However, the possible role of perineuronal nets (PNN), a member of the tetrapartite synaptic unit, is still elusive. We aimed to investigate alterations in PNN structure mainly encapsulating parvalbumin positive interneurons (PV-IN) in a rat model of LID.Methods: 6-OHDA toxin-injected hemiparkinsonian, sham-operated, and naïve Wistar male rats received eit