Topic: Parvalbumin-positive neurons

Brain activity depends on GABAergic inhibitory interneurons. Dlx5 and Dlx6 are two closely related homeobox genes, expressed by the telencephalic ganglionic eminences. In the adult brain, Dlx5/6 are expressed in most cortical GABAergic interneurons.In the prefrontal cortex, Parvalbumin-positive neurons (PV-neurons) are involved in cognitive functions, and their maturation is critical for cognitive development. Using mouse lines in which Dlx5/6 are either invalidated or overexpressed in GABAergic neurons, we have recently shown that the adult density of PV-neurons is directly correlated to Dlx5

Understanding the intricate interplay between dendritic, cytoskeletal organization, and synaptic compartmentalization is crucial in deciphering neuronal function. While much is known about the role of actin filaments and microtubules in excitatory neurons, their organization in inhibitory GABAergic neurons remains relatively understudied. This research delves into the distinct cytoskeletal organization within aspiny GABAergic Parvalbumin-positive neurons, particularly focusing on their dendritic microtubule arrangement and its interaction with postsynaptic sites. Unlike excitatory neurons wher