Topic: PC12 cells

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Neuronal cells, once impaired, do not undergo spontaneous regeneration; consequently, the disease persists beyond the onset of symptoms. There is a growing recognition of the need for treatments that could protect neurons and potentially modify the disease course because current PD treatments primarily address symptoms without halting the disease progression. Autophagy, a cellular process clearing damaged organelles and proteins, has emerged as a poten

The deposition of amyloid-β (Aβ) peptides has been implicated as a one of pathological hallmark of Alzheimer's disease (AD). Increasing evidence indicates that Aβ initiates oxidative stress and a vicious cycle of mitochondrial damage, leading to apoptotic neuronal death. Pinocembrin (5,7-dihydroxyflavone), a major flavonoid found in honey and propolis, has shown significant neuroprotective property by suppressing Aβ cleaving enzyme in our previous study. The present study investigated a novel anti-AD effect of pinocembrin on mitochondrial dysfunction and apoptosis against Aβ injury. Neurotoxic