Topic: perforant path

The dentate gyrus (DG) plays a key role in the emergence of spatial and contextual map representation within the hippocampus during learning. Granule cells (GCs) of the DG receive their major spatial cortical input from the medial entorhinal cortex (MEC) via the perforant path. To determine whether inputs from the MEC (in particular layer II stellate cells) play a role in the capacity of the DG to differentiate between different environments, we aim to modulate their activity using DREADDs. Thanks to these pharmacogenetic tools, we can de- or hyper-polarize MEC-layer II stellate cells during e

The dentate gyrus (DG) serves as an information gateway to the hippocampal formation. It receives sensory information from entorhinal cortex via perforant path (PP) and can be subdivided into parts including a supra- and an infrapyramidal blade. Typically, synaptic plasticity within the DG has mostly been examined in the suprapyramidal blade, whereas little is known about the extent to which synaptic plasticity is expressed and maintained in the infrapyramidal blade.This study compared synaptic plasticity in both blades of the DG that was evoked by patterned electrophysiological stimulation of

Episodic memory (EM), the remembrance of an event with spatiotemporal (what-where-when) information relies on the hippocampus (HP) and the entorhinal cortex (EC). The superficial layers of the EC provide the primary input to the HP via the perforant path, so we use a mouse line capable of expressing chemogenetic inhibitors in a particular set of projection neurons of EC Layer II (EC stellate and fan cells) to examine the precise role played by EC inputs in different forms of episodic memory. For this we employ an episodic memory task with both olfactory and spatial twin variants. Both are iden

The Dentate Gyrus (DG) receives rich multimodal inputs from the entorhinal cortex through the perforant path, and it translates them into a sparse code for the CA3. During the exploration of new environments, groups of DG granule cells (GCs) become active and form new memories. The activity of GCs is strongly modulated by a large network of inhibitory interneurons (INs) that allow the sparsification and orthogonalization of cortical inputs. Recently, a novel population of GABAergic INs expressing the Neuron-Derived Neutrophic Factor (NDNFIs) has been identified as a key component in the modula