Topic: perinatal asphyxia

The gestational gut microbiota exerts significant influence on infant neurobehavior and postnatal brain resilience. This study addresses challenges encountered in assessing the effects of gestational antibiotic administration (GAA) and perinatal asphyxia (PA) on offspring neurodevelopmental reflexes.A preliminary study evaluated the effects of an initial antimicrobial cocktail (GAA-1) and PA on Wistar rat offspring. GAA-1 was initiated on gestational day 11 using a cocktail comprising ampicillin, vancomycin, neomycin, clindamycin, and amphotericin-B, followed by PA exposure on postnatal day (P

The aim of this study was to address the urgent global need for an effective therapeutic strategy against acute stroke and perinatal asphyxia. A promising answer to limitations of currently existing therapies might be the newly designed Pathway Preferential Estrogen-1 (PaPE-1). Estrogen receptor-mediated signaling is pivotal for neuroprotection, and its impairment during hypoxia/ischemia may increase the risk of cerebral infarction. Our goal was to selectively activate non-nuclear estrogen receptors signaling, providing a wide therapeutic window and minimizing adverse hormonal effects associat