Topic: periodontitis

Research has extensively explored the influence of Periodontitis on Alzheimer’s disease (AD), identifying its role in accelerating the disease via systemic inflammation and bacterial invasion to the brain. Additionally, investigations into titanium oxide nanoparticles (Ti NP) and AD have shown significant effects on cognitive ability in vitro and in vivo. This study aims to assess the synergistic impact of Ti NP and P. gingivalis (Pg), factors involved in periimplantitis pathogenesis, on the neuroinflammatory response of mouse microglia cells (BV2) in vitro.Using a BV2 and RAW (separate contro

Recently, neurodegenerative diseases are more often linked with oral bacteria-driven infections. However, it is not clear how central nervous system pathologies root from infections of the oral cavity. Porphyromonas gingivalis (Pg) is a key-stone pathogen in periodontitis, a chronic inflammatory disease of the gingival and teeth-supporting structures. Many studies suggest that differences in infection severity and systemic pathologies are linked with different Pg strains and produced virulence factors. In this study, we used a zebrafish (Danio rerio) infection model, widely used in biomedical