Topic: peripheral nerves

The dynamics of biological systems depend on complex cell-cell interactions. Extracellular vesicles (EVs) are nanosized vehicles of intercellular communication which shuttle several molecules from cell to cell, thus influencing relevant biological processes. Previous literature based on EV isolation from cell culture medium highlighted how EVs in the peripheral nervous system could be important mediators in the molecular dialogue between neurons and Schwann cells. Here, we aim to extract EVs directly from peripheral nerve tissue, as this would give the unique opportunity to characterize EVs fr

Neural interfaces to peripheral nerves are increasingly employed for basic research, neuroprosthetics, and bioelectronic medicine (‘electroceuticals’). We previously established a pipeline for hybrid electromagnetic-electrophysiology modeling of nerve stimulation on the o2S2PARC platform for collaborative, FAIR, and reproducible computational neurosciences. It leverages histological data to generate a detailed anatomical model of the nerve microstructure and to functionalize it with populations of fiber neuro-dynamics models (myelinated/unmyelinated, statistical distributions of fiber types an