Topic: perirhinal cortex

Ventral pathway circuits are constituted by the interconnected brain areas that are distributed throughout the brain. They are primarily involved in processing of object related information in brain. However, their role in object recognition memory (ORM) enhancement remains unknown. In this study, we show that an activation of each of the brain areas interconnected to ventral pathway circuits individually induced enhancement in ORM; however, same treatment in brain areas not interconnected to ventral pathway circuits produced no effect. Further study in perirhinal cortex (PRh), area V2 of visu

Hierarchical processing has been shown to underlie complex functions such as invariant object coding. The perirhinal cortex (PER) is a higher-order region that sits at the apex of such processing streams and is involved in object recognition. Although it receives tactile information from barrel cortex (wS1) and secondary somatosensory cortex (S2), it is unclear how PER neurons respond to such stimuli. To address this, we performed population recordings of the barrel and perirhinal cortices of head-fixed mice while an object deflected their whiskers. Both ipsi- and contralateral stimulations we

The perirhinal cortex (PER) integrates and transfers information from cortical areas to the hippocampus, which is crucial for memory-related tasks, particularly novel object recognition. However, how the PER gates information transfer is largely unknown. During learning and novelty-induced exploration, the locus coeruleus releases noradrenaline, a candidate for modulating synaptic plasticity within the PER. We explored the hypothesis that noradrenaline could transiently increase the excitability of the PER network, enhancing information transfer toward the hippocampus and ultimately leading to

The perirhinal and parahippocampal cortices are key components of the medial temporal lobe memory system and essential for the processing of spatial and declarative memory. In humans, major changes in declarative memory capacities occur within the first seven years of life, but until recently, the neurobiological substrates underlying these changes remained hypothetical. Previous studies have shown that distinct regions, layers and cells of the hippocampus and entorhinal cortex exhibit different profiles of structural and molecular development during early postnatal life. Accordingly, the diff