Topic: peritumoral cortex

Glioblastoma Multiforme (GBM) is the most aggressive form of brain tumors. It affects 3 in 100,000 people and has a median survival of 15 months. GBM is known to infiltrate the surrounding brain parenchyma, interacting with neuronal tissue. Specifically, tumoral cells induce neuron hyper-excitability while peritumoral cells seem to regulate tumor proliferation and progression. This project aims to investigate how the plastic rearrangement of cortical areas occurs in glioma-bearing animals. We took advantage of Thy1-ChR2 transgenic mice, injected with two syngeneic lines of murine glioma cells

High-grade gliomas (HGGs) include astrocytoma and glioblastoma. They are characterized by aggressiveness, intra- and inter-tumor heterogeneity, and infiltrating ability, decreasing the efficacy of resection and therapies. Glioma invasiveness depends on the dynamic interaction between glial cells, mainly microglia, and astrocytes. Accordingly, extra-CNS metastasis remains a rare clinical entity. Astrocytic connexin43 (Cx43) is under microglia control. Cx43-mediated signaling profoundly impacts HGGs invasion and could be a potential target in the glia-HGGs communication. However, it needs furthe