Topic: perseverative errors

In this world of unexpected change, animals face a critical trade-off between retaining older information and facilitating new learning. Dendritic spines, where excitatory synapses are located, represent the basic structural and functional unit of learning and memory at the neuronal level; spines are formed and/or modified during learning to support behavioral demands. However, how the interplay between plasticity and stability in dendritic spines is implemented to accommodate adaptations in behavior remains unclear. We investigated this question in head-fixed mice performing a rule-switch beh

Flexibility to changing environments is vital for survival and daily functioning. Impaired flexibility is a feature of many pathological conditions, including obsessive-compulsive disorder and schizophrenia, which result in a dissociation between actions and goals. The prevailing theory is that goal-directed actions support flexible behaviour, and impaired flexibility results from habit formation due to extended training, also called overtraining, whereby responding becomes less dependent on outcome value (e.g., compulsive responding).This dual-system theory suggests that overtraining results