Topic: PFOA

Perfluorinated compounds (PFCs) are organofluorine compounds containing carbon-fluorine and carbon-carbon bonds. They are used as water and oil repellants in clothes and pharmaceutical tablets, but have been found to cause neurotoxicity. However, it remains elusive whether PFCs affect neural survival or activity, or whether they alter different neuronal regulations in the brain. Additionally, there is a paucity of data on the regulatory mechanisms involved in PFCs-induced neural toxicity.In the current study, we report that PFOA or PFHpA differentially alter neural survival and activity in pri

The increasing environmental spreading of perfluoroalkyl substances (PFASs) raises concerns for theirimpact on human health. PFASs are synthetic chemicals widely used in industrial and consumerproducts to make surfaces repellent to water and lipids. Once ingested or inhaled, PFASs arebioaccumulated in the blood, liver, kidney, and brain of various species with an elimination half-lifein humans of 3-5 years. In a previous publication, we highlighted for the first time that theaccumulation of PFASs can alter the development of human dopaminergic neurons (Di Nisio et al.,2022). This finding, toge