Topic: photophobia

Migraine is a neurological disorder manifested by throbbing pain, allodynia, as well as light sensitivity (photophobia). Despite continuing research, the pathogenesis of the disease is not precisely understood. Structures implicated in migraine formation, including the trigeminal ganglia and trigeminal nucleus caudalis, exhibit a particularly high expression of Nociceptin Opioid (NOP) receptors. The aim of the study was to compare the effect of selective and non-selective NOP receptor agonists on acute migraine symptoms induced by systemic administration of nitroglicerin (NTG). NTG induces mig

Cystinosis is a rare, childhood lysosomal storage disorder caused by mutations in cystinosin, the transporter responsible for cystine from the lysosome to the cytosol. In cystinosis, mutated cystinosin causes cystine crystal accumulation and cell death. Photophobia, or abnormal sensitivity to light, is an early symptom of the disease and can be debilitating for patients. Historically, this photophobia has been attributed to ocular corneal cystine crystal accumulation, but eyedrops prescribed to disrupt these crystals do not fully alleviate symptoms. Furthermore, photophobia is known to have a

Transient receptor potential ankyrin 1 (TRPA1) plays a pivotal role in migraine pathogenesis via regulating cortical spreading depression, neuroinflammation, hyperalgesia and trigeminovascular system activation and sensitization. However, whether TRPA1 could affect photophobia, a symptom that affects ~80% migraineurs, is unknown. In this study, we examined whether TRPA1 activation triggers photophobia, and displays a gender-specific difference in photophobia behavior. C57BL/6J mice were used to assess mouse behavior in both dark and light compartments of a chamber. The photophobia behavior was