Topic: pilocarpine

Temporal lobe epilepsy (TLE) is a focal epilepsy often refractory to anti-epileptic medications. Hippocampal sclerosis and lesions in the temporal cortex are associated to mesial TLE and neocortical TLE, respectively. In both cases, histopathological alterations in other areas have been reported. Here, we investigated the possible correlation between lesioned location and severity of the epileptic syndrome.Status epilepticus (SE) was induced by pilocarpine injection in Sprague-Dawley rats and was terminated 30 minutes later by ketamine/diazepam. Two weeks later, rats were implanted with depth

Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures poorly controlled by antiseizure medications in over 30% of patients. The current study aims to investigate the most epileptogenic areas in a TLE animal model using high-density EEG.Sprague Dawley male rats were injected intraperitoneally with pilocarpine to induce the status epilepticus (SE) terminated 30 minutes later by ketamine/diazepam. Two weeks later animals were implanted with epidural electrodes in the frontal cortex and depth electrodes in several temporal areas. Video-EEG recordings (24h, >3 days/week

Rhythmic electrical activity in the central nervous system is involved in cognitive functions in many animals and is also found in the olfactory centers of terrestrial gastropods, including slugs and snails. The procerebrum, the secondary olfactory center of the terrestrial slug (Limax valentianus), forms a unique layered structure that generates spontaneous, synchronized oscillatory activity all the time to process odor-related information. Previous studies have shown that synchronous oscillatory networks are spontaneously reorganized as neurites elongate in dispersed cell culture of procereb

Status epilepticus (SE) is a prolonged, recurrent seizure leading to neuronal damage. Given the limitations of existing treatment modalities, exploring new alternatives is imperative. Emerging research suggests that inflammatory processes are implicated in epileptogenesis. Apigenin (AP), an antioxidant and anti-inflammatory flavonoid, demonstrates neuroprotective effects in brain disorders. Nevertheless, its significance in status epilepticus remains unstudied. Therefore, we investigated whether AP alleviates pilocarpine (PLO)-induced SE neuropathology. We propose that AP may reduce SE by atte