Piriform cortex

…strength between neurons in the Piriform cortex (PCx) following mice learning an odor discrimination task. Our results suggest that an assembly forms after learning, but

Animals encode sensory stimuli with precisely timed activity across modalities. For example, mice can rapidly recognize odors, independent of their concentration, based on complex spatiotemporal patterns of mitral and tufted cell (MTC) activity in the olfactory bulb. Yet, it remains unknown how sequential MTC activity is organized, and what role sequential activity plays in guiding perception. Here, we performed fast 2-photon calcium imaging of hundreds of MTCs with sub-sniff temporal resolution to a battery of odors. We constructed a space of MTC tuning using the pairwise correlations between

…system, the olfactory bulb (OB) and piriform cortex (PCx) are responsible for preliminary odor encoding and corresponding memory storage respectively. Recent evidence demonstrated the dynamic nature of OB and PCx odor representations upon frequent repetition of the same odors over days, and this phenomenon, termed representational drift, should be the consequence of highly plastic nature of biologically constrained synapses in the olfactory system. In this work, we buil

…then through the lateral entorhinal cortex to the hippocampus, whereupon symptoms of dementia become apparent. Intracerebral inoculation of healthy rodents with oligomeric amyloid-beta(1-42) results in impairments of hippocampal information processing and storage (doi: 10.3389/fnbeh.2015.00103).To what extent this also affec

…NPS receptor in olfactory regions like piriform cortex, suggests that there may be a functional relationship between NPS and epileptic activity.The aim of this study was to investigate the effects of suppression of the NPS receptor pathway on epileptiform activity in piriform cortex. Acute brain slices were obtained from 6-8 weeks old C57BL/6 mice.

Recognizing and remembering social conspecifics is crucial for the survival of an organism, but it remains unclear how this information is represented in the brain. Previously, we identified populations of basolateral amygdala (BLA) neurons in the freely-moving rat that were highly tuned to distinct naturalistic stimuli such as male or female conspecifics and food. These neuronal populations showed stable reactivation across multiple presentations of stimuli in the same environment. To understand whether experience can modify this social representation, we recorded from large populations of ne

The primary olfactory cortex (piriform cortex) is a well-established epileptogenic site with the potential to amplify and generalize seizures. Disinhibition, caused by the synaptic inhibition of inhibitory neurons by other inhibitory neurons, increases the excitability of principal neurons and has been proposed as a contributing factor in numerous neurological diseases, including epilepsy. Therefore, unravelling inhibitory microcircuits in the piriform cortex may uncover new therapeutic avenues for treating epilepsy. Our study used whole-cell recordings from identified classes of inhibitory in

…in the olfactory bulb and frontal cortex, the number of GABAergic postsynaptic puncta in primary olfa

…project to different regions of piriform cortex and form parallel circuits wherein TCs interact mainly with the anterior olfactory nucleus (AON), and MCs with piriform cortex (PC) proper. Experiments have revealed that (1) MCs are primarily driven by TCs, perhaps why (2) MC responses come later in the sniff cycle than TCs; (3) MCs receive excitatory cortical feedback from the AON; and (4) MC responses are

…and tufted (M/T) cells to downstream piriform cortex (PCx), forming a shallow circuit through which to assess how temporal patterns of receptor activity are enc

…higher olfactory areas, including the piriform cortex(PCx). The PCx receives input from association areas(e.g., orbitofrontal cortex) and sends dense feedback that selectively modulates one of the OB out

Animals depend on their senses for survival. Mice, who rely on olfaction to navigate the world, can rapidly identify odors within a single sniff across a wide range of concentrations. In the mouse olfactory bulb (OB), mitral and tufted cells (MTCs) respond to odors by changing both the rate and timing of spikes relative to inhalation, resulting in reliable, odor specific sequences that evolve over a single sniff. However, it remains unknown how sequential MTC activity is organized. Specifically, what defines the order in which MTCs fire, and what information is encoded in these sequences? To a

…For example, in piriform cortex, which is commonly considered primary olfactory cortex, the cells responsive to a given odor are completely uncorrelated with those activated by the same odor two weeks later (Schoonover et al., 2021). This would seem to imply that piriform cortex, like other brain regions whose activity appears to drift, is useless for the retrieval of associative memories learned several weeks prior. Howeve

…olfactory system, recordings from the piriform cortex demonstrate drift in the representation of a single olfactory stimulus, despite apparently stable odor identification. Such drift is characterized by a decay in the self-similarity of the stimulus representation vector as a function of the time between the recordings. Additionally, the rate of the decay was shown to be smaller for more frequent stimuli

…that the activity in the olfactory piriform cortex (PC) of mice encodes not only odor information, but also non-olfactory variables associated with the behavioral task. By developing an associative ol

…of odor associations in the olfactory cortex. Computational modeling and behavioral studies suggest that cholinergic modulation could improve sensory processing and learning while preventing pro-active interference when task demands are high. However, how sensory inputs and/or learning regulate incoming modulation has not yet been elucidated. We here use a computational model of the olfactory bulb, piriform cortex (PC) and hori

…population activity in the olfactory cortex to understand the integration of olfactory and spatial information. Primary olfactory (piriform) cortex (PCx) has long been recognized as a highly associative