Topic: PLX3397

Identification of Alzheimer's disease (AD) risk loci highlighted the role of microglia in the pathogenies of AD. Nevertheless, whether microglia are beneficial or detrimental in AD is still debated. Several studies tested the contribution of microglia to amyloid pathology by microglia depletion, resulting in seemingly contradictory results. Here, we aimed to unify these conflicting findings by systematically testing microglia depletion at various stages of disease progression in mice.Depletion of microglia by PLX3397 treatment before the onset of amyloid plaques in AppNL-G-F mice resulted in a

Dementia is a term for several diseases that affect memory, thinking, and daily activity performance. The most prevalent form of dementia is Alzheimer’s disease (AD), which explains 60-70% of dementia cases (World Health Organization [WHO], 2023). AD is a neurodegenerative disorder characterized by brain atrophy, gliosis, Abeta and tau proteinopathies, and vascular dysfunction. Previously, our group has described that a non-productive angiogenesis (NPA) phenomenon occurs around Abeta plaques, giving rise to disassembled, low-perfused vascular structures, which we have called vascular scars (Va