Topic: PM10

Exposure to air pollution, and particularly to particulate matter (PM), has been associated with higher rates of Multiple Sclerosis (MS) relapses and increased neuroinflammation in MS patients, suggesting that PM exposure may contribute to MS exacerbation. To address this issue, we have combined the induction of MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) in mice – the most used animal model of MS - with PM10 exposure. Mice were exposed to PM10 dosages relevant for human exposure before the immunization or during the pre-symptomatic phase. In both cases, PM10 exposures did

Evidences linking air pollution and neurodevelopmental disorders are gaining a great support on the last years. Specifically, traffic-related air pollution (TRAP) has proven to negatively affect cognitive and behavioral development in children. Among different types of air pollutants, particulate matter (PM) is the one most linked with these adverse consequences. On the other hand, APOE is a polymorphic human gene that has three different alleles (e2, e3, e4), being the e3 the most prevalent allele in general population. Moreover, the e4 allele has been associated with increased risk of Alzhei