Topic: polycystic ovary syndrome

Reproductive disorders are associated with neuroendocrine dysregulation in the hypothalamic-hypophysis-gonadal (HHG) axis, which can result from a defective production and action of the neuropeptide gonadotropin-releasing hormone (GnRH), the master regulator of reproduction. We have previously shown that SELENOT, a new thioredoxin-like selenoprotein highly expressed in endocrine and neuroendocrine cells, plays a role in hormone secretion. However, whether SELENOT is involved in neuroendocrine regulatory mechanisms that impinge on vital functions such as reproduction, is totally unknown. We fou

Polycystic ovary syndrome (PCOS) stands out as the most prevalent reproductive disorder affecting women, impacting hormonal and metabolic equilibrium. It can manifest as hyperandrogenism, insulin resistance, anovulation, and infertility. PCOS is associated with various symptoms such as obesity, hirsutism, and acne, which, in turn, elevate the risk of conditions like endometrioma, type 2 diabetes, cardiovascular disease, and irritable bowel syndrome. Previous data from our research indicated that PCOS accelerates pain perception in patients, yet the underlying mechanism remains elusive.In this