Topic: population spiking activity

Brain networks have the remarkable ability to adapt to neuron loss; however, little is known about how population spiking activity is affected quantitatively and even less is known about how populations adapt to restore behavior. Here, we analyzed the impact of neuron loss on population correlation structure using numerical simulations, a spiking neural network model, and in vivo spiking data from a lesion technique in which focal neuron loss is created through chronically implanted electrode arrays in awake-behaving animals. This easily-repeated perturbation allows neuroscientists to track t

The hippocampus plays a key role in cognitive map formation. As an abstract model of the world, it has to balance the demands of accurate, yet general, predictions. Despite a long-lasting interest in hippocampal computations, the specific contributions of distinct hippocampal subregions remain debated. Evidence from rodents and humans suggests that subregion CA3 represents event-specific information, while subregion CA1 encodes more generalized information.The free-energy principle entails that neural networks with more generalized representations operate closer to criticality, where external