Topic: population vector

Recent chronic imaging experiments in mice have revealed that the hippocampal code exhibits non-trivial turnover dynamics over long time scales. Specifically, the subset of cells which are active on any given session in a familiar environment changes over the course of days and weeks. While some cells transition into or out of the code after a few sessions, others are stable over the entire experiment. The mechanisms underlying this turnover are unknown. Here we show that the statistics of turnover are consistent with a model in which non-spatial inputs to CA1 pyramidal cells readily undergo p

Classic studies show that in many species – from leech and cricket to primate – responses of neural populations can be quite successfully read out using a measure neural population activity termed the population vector. However, despite its successes, detailed analyses have shown that the standard population vector discards substantial amounts of information contained in the responses of a neural population, and so is unlikely to accurately describe how signal communication between parts of the nervous system. I will describe recent theoretical results showing how to modify the population vect

Different stimuli elicit different transient neural responses in the brain. How is the information represented in the parallel neuronal activity of a neuronal population? We investigate this question in Neuropixel recordings of awake behaving mice by inferring the stimulus class (e.g., visual or tactile) from the activity. To quantify the separability, we use an optimally trained linear readout, which can be understood through the framework of Bayesian inference. We find that separability only depends on three geometric properties of the neuronal population vector, described by cones within th