Postoperative delirium

…with clinical assessments of postoperative delirium to identify baseline markers of vulnerability and consider practical ways to improve recovery. It connects sleep architecture, biological and environmental influences, and preoperative risk with proactive, sleep-informed patient care. Chhajed is a Clinical Research Coordinator at Massachusetts General Hospital. Online via Zoom Webinar. Tuesday 29 September 2

Postoperative delirium (POD), expressed from mild forms such as short cognitive impairments to chronic cognitive deficits or death, is relevant in up to 80% of patients after surgery under general anesthesia (GA). The systemic and mechanistic relationship between preoperative anxiety (POA) and POD is largely unknown. A preoperative anxious phenotype and the identification of sleep impairments due to it hold the strong potential to establish predictive parameters for POD. These discoveries may further elucidate the neuronal mechanisms underlying POA and POD. 37 C57BL/6N male mice (12-weeks-old)