Topic: postsynaptic scaffold

Synaptic dysfunction is a key feature of SHANK-associated disorders such as autism spectrum disorder, schizophrenia, and Phelan-McDermid syndrome. Since detailed knowledge of their effect on synaptic nanostructure remains limited, we investigated such alterations in ex11|SH3 SHANK3-KO mice combining expansion (ExM) and STED microscopy. This enabled high-resolution imaging of mosaic-like arrangements formed by synaptic proteins. We found distinct shape-profiles as fingerprints of the murine postsynaptic scaffold across brain regions and genotypes, as well as alterations in the spatial and molec

Different neurological diseases are characterized by an imbalance between excitatory and inhibitory synapses, including epilepsy or autism spectrum disorders (ASD). One of many genes linked to these conditions is the scaffold protein neurobeachin (NBEA), which has been previously described as essential for receptor targeting to the plasma membrane. While its role at excitatory synapses has been studied extensively, NBEA function at inhibitory synapses is still barely understood. Here we report that NBEA is recruited to the GABAergic synapses in an activity-dependent manner and interacts with t