Topic: Pramipexole

Impulse control disorders (ICDs) are characterized by irresistible urges to act without foresight and an impaired inhibition of these behaviors, which constitute an important feature of substances or behavioral addictions, such as gambling, hypersexuality, or compulsive eating. In Parkinson’s disease patients, dopaminergic D2-receptor (DA D2R) agonist treatment pramipexole (PPX) has been shown to trigger ICD’s for 2/3 of them, highlighting the involvement of DA transmission in ICDs onset, especially through the D2R family.Striatal D2R transmission is acting principally through the indirect pat

Dopamine receptors (DRs) are G protein-coupled receptors (GPCRs) expressed in the central nervous system. When activated, DRs can trigger different downstream signal transduction cascades based on which they are divided into two major classes: D1-like, which includes excitatory D1 and D5 receptors, and D2-like, including inhibitory D2, D3 and D4 receptors. Drugs acting on DRs are used to treat several neurological disorders, like Parkinson´s disease (PD), schizophrenia, depression or bipolar disorders. PD, for example, is caused by the early death of dopaminergic neurons in substantia nigra pa