Topic: Prenatal stress

The prenatal microbiome influences offspring health, by potentially altering postpartum maternal behavior. Identified as microbiome disruptors, prenatal stress and gestational antibiotic administration pose risks to maternal and offspring health.We conducted two studies exploring the impact of 1.Antibiotic administration and 2.Stress during gestation on postpartum maternal behavior using Wistar rats. Additionally, we examined the potential benefits of a multi-strain probiotic intervention.In the first study, a subgroup of pregnant rats received an antibiotic cocktail (ampicillin+vancomycin+neo

The intrauterine milieu significantly influences the future health trajectory of offspring, wherein adverse prenatal conditions can induce aberrant fetal neurodevelopment with enduring consequences. Prenatal stress represents a notable adverse condition known to affect offspring health detrimentally, often correlated with dysregulations in gut microbiome composition. Therefore, we aim to investigate the impact of prenatal stress on offspring neurodevelopment and to evaluate the potential mitigative role of probiotics. Randomly chosen pregnant female Wistar rats underwent daily restraint stress