Topic: primary cilium

Neurodevelopmental disorders (NDDs) are often associated with mutations in mitotic genes rather than in genes specifying neuronal functions. Several mitotic regulators are functionally repurposed to new roles during neurodifferentiation. CENP-F, a kinetochore- and microtubule-interacting protein with well-characterised mitotic functions, is being growingly identified for harbouring mutations in primary microcephaly and in the Strømme syndrome, an NDD classified as a ciliopathy. The mechanism through which mutant CENP-F contributes to these NDDs remains elusive.To gain insight into the implicat

The serotonin 5-HT6 receptor (5-HT6R) is a G protein-coupled receptor only expressed in the central nervous system. It is a promising target for treating cognitive deficits observed in neurodevelopmental diseases, such as autism spectrum disorders (ASD). Our team has demonstrated a crucial role for the 5-HT6R in neurodevelopment. It participates in neuronal migration, the initiation of neurite growth and dendritic arborization, through interactions with different protein partners. We also confirmed that this receptor is mainly expressed in the primary cilium of neurons and astrocytes, except f

The primary cilium, a microtubule-based organelle that extends into the extracellular space, plays a crucial role in signal transduction. It acts as an 'antenna' for signal conversion through different pathways, containing various types of proteins, such as G-protein-coupled receptors (GPCRs). Notably, it is involved in the regulation of glucose homeostasis, a vital process for cellular function and energy balance, which includes glucose detection associated with both metabolic (GLUTs and glucokinase) and independent mechanisms. Sweet taste receptors (STR), which are GPCRs composed of subunits