Topic: primary cortical neuronal cultures

Accumulating evidence indicates that the plasticity-inducing effects of conventional antidepressant drugs are mediated by their direct binding to TrkB. In addition, it has recently been reported that psychedelics LSD and psilocybin, also bind to TrkB with higher affinity than antidepressants. In this study, we investigated whether psychedelics and classical antidepressants promote TrkB dimerization and neurotrophic signalling in a differential manner. The effects of psychedelics on the TrkB dimerization dynamics and neurotrophic signalling associated with plasticity were studied treating N2a c

Claudins are cell adhesion molecules that form a crucial component of the epithelial cells and Blood-brain barrier in vertebrates, and are structurally conserved across phyla. In their canonical role, claudins form the integral components of tight junctions where they function to regulate barrier properties. However, their interaction with other non-tight junction proteins, such as actin cytoskeleton, EpCAM suggests the possibility of non-canonical roles for claudins. Recently claudins have also been discovered in glia and neurons. Further studies have indicated a link between the loss of clau