Progesterone

Wearable sensors that detect and quantify biomarkers in retrievable biofluids (e.g., interstitial fluid, sweat, tears) provide information on human dynamic physiological and psychological states. This information can transform health and wellness by providing actionable feedback. Due to outdated and insufficiently sensitive technologies, current on-body sensing systems have capabilities limited to pH, and a few high-concentration electrolytes, metabolites, and nutrients. As such, wearable sensing systems cannot detect key low-concentration biomarkers indicative of stress, inflammation, metabo

Internal states flexibly shape social behaviour. Females across species for instance become more receptive during Estrus, more parental during pregnancy, and more aggressive during hunger. While most research has focussed on the behavioural role of individual internal states, animals exhibit multiple states at any given time. How and where the brain integrates combinations of states to shape behaviour remains largely unknown. Here we report that hunger and estrous state together orchestrate a switch to pup-directed aggression in female mice. This behavioural switch results from inhibition of t

…the protective effects of the hormone progesterone (P4) against CH‐induced OS and neurodegenerative pathologies i

…the estrus phase characterized by low progesterone levels, compared to females in non-estrus phase with high

…and nonhuman primates estrogen and progesterone influence the central nervous system across a range of spatiotemporal scales. Yet, their influence on the structural and functional architecture of the human brain is largely unknown. Here, I highlight findings from a series of dense-sampling neuroimaging studies from my laboratory designed to probe the dynamic interplay between the nervous and endocrine systems. Individuals underwent brain imaging and venipuncture every 12-24 hours for 30 consecutive days. These procedu

…produced hormones – estrogen and progesterone. As a result of these fluctuations, women experience different symptoms in their bodies – their immune system changes (Sekigawa et al, 2004), there are changes in their cardiovascular and digestive system (Millikan, 2006), as well as skin (Hall and Phillips, 2005). But these hormone fluctuations produce major changes in their behavioral pattern as well causing: anxiety, sadness, heightened irritability and anger (Severino and Moline, 1995) which