ePoster · Neuroscience
Niklas Rilke, Mona Shaygan Tabar, Baffour Sarpong, Katharina Lemhoefer, Clarissa Lohmann, Alina Blusch, Anna Meichsner, Zhixiao Wu, Melissa Sgodzai, Adriana Rehm, Pia Renk, Barbara Gisevius, Anna-Lena Fisse, Jeremias Motte, Thomas Grüter, Konstanze Winklhofer, Ralf Gold, Kalliopi Pitarokoili · FENS Forum 2024
The chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease affecting myelin and neural structures of the PNS. In recent studies, propionic acid (PA) showed anti-inflammatory and disease modifying effects in multiple sclerosis patients. Additionally, PA exerted neuroprotective and neuroregenerative effects in PNS in vitro cell cultures of Schwann cells (SC) and dorsal root ganglia (DRG). In this study, we investigate the potential effects of PA on SC derived from rats sciatic nerve. First, SC were treated with IFNγ to induce MHC-II receptor expression, which was measu
ePoster · Neuroscience
Pikria Khomasuridze, Giorgi Lobzhanidze, Nadezhda Japaridze, Mzia Zhvania, Fuad Rzayev, Eldar Gasimov · FENS Forum 2024
Propionic acid (PA), a short-chain fatty acid and a metabolite of the gut microbiome, plays a significant role in health but has been associated with various pathologies, including autism spectrum disorder (ASD). Experimental studies in rodents have shown that elevated levels of PA can induce molecular and immune changes similar to those observed in ASD (MacFabe, et al.). However, limited knowledge exists regarding its impact on brain structural integrity. In this study, we examined the effects of a single intraperitoneal injection of PA at a dose of 175 mg/kg on adolescent male Wistar rats. S
ePoster · Neuroscience
Mzia Zhvania, Nadezhda Japaridze, Giorgi Lobzhanidze, Nino Pochkhidze, Pikria Khomasuridze · FENS Forum 2024
It is known that propionic acid (PPA) administration in rodents provokes multidirectional responses that are reminiscent to those observed in autism. However, whether PPA affects the ultrastructure/synaptic architecture of regions of autistic brain has not been adequately elucidated. In the present research, we used electron microscopic analysis to evaluate the effect of single intraperitoneal injection of moderate dose of PPA (175 mg/kg) on the ultrastructure of the hippocampus and medial prefrontal cortex of male adolescent Wistar rats. Furthermore, using morphometric electron microscopic ap