Topic: protein kinase C

Cardiac vagal motor drive originates in the brainstem's cardiac vagal motor neurons (CVNs). Despite well-established cardioinhibitory functions in health, our understanding of CVNs in disease is limited. There is a clear connection of cardiovascular regulation with metabolic and energy expenditure systems. Using high fat diet as a model, this talk will explore how metabolic dysfunction impacts the regulation of cardiac tissue through robust inhibition of CVNs. Specifically, it will present an often overlooked modality of inhibition, tonic gamma-aminobuytric acid (GABA) A-type neurotransmission

The emergence of spontaneous activity in the form of synchronized bursting events (SBE) is considered to play a crucial role in activity-dependent development of neuronal networks. As inhibition matures, the spatiotemporal structure of activity becomes increasingly influenced by the balance between excitation and inhibition (E/I). Moreover, intricate interactions between excitatory (ENs) and inhibitory (INs) neurons may arise during their activity-dependent structural differentiation. However, how the resulting spatial embedding of INs and ENs in a network impacts on the spatiotemporal structu