Topic: PS19 mice

Clinical data strongly support olfactory impairment as an early indicator of neurodegenerative diseases (ND), including Alzheimer’s disease. In AD patients, neurofibrillary tangles (NFTs) have been identified in the entorhinal cortex and olfactory bulbs, both crucial in olfactory information processing. We therefore investigated the hypothesis that typical ND lesions could appear early in olfactory system regions.We used a tauopathy mouse model (PS19 mice) expressing the human tau protein (1N4R) carrying the P301S mutation. PS19 mice develop NFTs-like inclusions at six months, leading to progr

Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia. During AD pathogenesis, tau is abnormally phosphorylated and aggregating within neurons. As a result of continuous intraneuronal tau aggregation, neurofibrillary tangles are formed. The aim of our project is to determine, whether inhibiting tau protein aggregation with a novel anti-aggregative compound “RE01” improves survival, behavior and neuropathology in a tau-transgenic mouse model. RE01 is an