Seminar · Molecular Neuroscience
The Synaptome Architecture of the Brain: Lifespan, disease, evolution and behavior
Seth Grant · Professor of Molecular Neuroscience, Centre for Clinical Brain Sciences, University of Edinburgh, UK
Mon, May 2, 2022 · 05:00 UTC
The overall aim of my research is to understand how the organisation of the synapse, with particular reference to the postsynaptic proteome (PSP) of excitatory synapses in the brain, informs the fundamental mechanisms of learning, memory and behaviour and how these mechanisms go awry in neurological dysfunction. The PSP indeed bears a remarkable burden of disease, with components being disrupted in disorders (synaptopathies) including schizophrenia, depression, autism and intellectual disability. Our work has been fundamental in revealing and then characterising the unprecedented complexity (>