Topic: PTZ-induced seizures

The sudden emergence of dangerous seizures is the defining feature of epilepsy, but how and when the brain changes dynamics remains enigmatic. From the perspective of dynamical systems theory, such critical transitions occur upon inconspicuous perturbations in highly interconnected systems presenting positive feedback loops and can be modeled as mathematical bifurcations between alternative regimes. Here, we sought to characterize dynamical signatures of impending seizures. We systematically verified the predictions of the model called ‘Epileptor’ that captures seizure dynamics in five differe

Aims: Interleukin-1β (IL-1β) in the central nervous system initiates a PI3K signaling cascade, involving crucial membrane phospholipids phosphatidylinositol (4,5)-bisphosphate (PIP2) and phosphatidylinositol (3,4,5)-trisphosphate (PIP3). While PIP2's role in epileptogenesis is known, our study investigates the unclear role of PIP3 using PTZ-induced epileptic mice, exploring its impact on epileptogenesis and associated sleep disruptions. Methods: Our hypothesis proposed a pivotal role for PIP3 in the molecular mechanism of seizures. We intraperitoneal administered low dose of PTZ once every two