Topic: purinergic signaling

In recent years, a pivotal role of gliotransmission in homeostatic synaptic plasticity has been highlighted and glial-derived ATP arises as a key contributor. However, very little is known about the glial non-vesicular ATP-release pathway and how ATP participates in the modulation of synaptic strength. In this work, we have analyzed the functional changes occurring in neurons upon chronic activity blockade and the role of the purinergic signaling, connexin43 and pannexin1 hemichannels in this process. By using hippocampal dissociated cultures, we showed that blocking connexin43 and pannexin1 h

Pregnant women at risk of premature labor receive a single treatment with the synthetic glucocorticoid dexamethasone (DEX) between the 24th and 34th week of pregnancy to ensure adequate maturation of the fetal organs. Due to the postponement of the due date, several doses are often administered. Because purinergic signaling plays an important role in the development of the auditory brainstem, particularly the cochlear nucleus, we investigated whether repeated DEX treatments affect components of the ADP-mediated (NTPDase2 and P2Y1R) and adenosinergic (CD73 and A1R) signaling systems. To compare

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and caudoputamen (Cp), leading to motor and non-motor symptoms. Neuroinflammation, oxidative stress, and imbalance in purinergic signaling significantly contribute to its progression. Current treatments fail to halt disease progression, necessitating novel approaches. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in alleviating PD symptoms, but its underlying mechanisms remain unclear. We investigated the effects of prolonged intermitten

Parkinson's disease (PD) is considered the second most common neurodegenerative disease in the world. Animal models based on exposure to Paraquat (Pq) or 6-hydroxydopamine (6-OHDA) have been used to better understand and find new therapies for PD. Purinergic signaling has emerged as a pivotal factor in the progression of PD. We assessed the influence of Pq or 6-OHDA on ATP metabolism as well as nucleotide and nucleoside-metabolizing enzyme activities and gene expression in adult zebrafish brain. Adult zebrafish were injected i.p. with saline (vehicle) or Pq (10 or 20 mg/kg) with two days of in