Topic: Purkinje cell activity

Optimal mammalian brain function relies on well-organized neuronal networks. GABAergic inhibitory interneurons precisely target subcellular regions to modulate synaptic inhibition and influence the timing of different neural networks. However, the molecular mechanisms guiding the assembly and stability of inhibitory synapses remain largely undefined. In this study, we explored an extracellular signalling pathway that uphold synaptic inhibition at a central inhibitory synapse. Using the cerebellar basket cell to Purkinje cell connection as a model, we discovered an unconventional paracrine path

The vestibulo-ocular reflex (VOR) stabilizes gaze by rotating the eyes into the opposite direction of the head. Optimal VOR function requires continuous calibration of the vestibular-to-motor transformation using retinal image slip as the sensory error; an operation that largely depends on the cerebellar flocculus. Here, we investigate how compensatory eye movements develop when retinal slip signals are largely absent, using mouse models with a defect in retinal motion detection. Congenital defects in the retinal photoreceptor-to-bipolar cell synapse eliminate the retinal ON-pathway and impair