PV interneurons

…mechanisms involving SST and PV interneurons. A circuit model demonstrates how cortica

Efficient spatial navigation in complex environments relies on the construction of an egocentric cognitive map. Recent studies have reported that subpopulations of excitatory neurons in the granular retrosplenial cortex (RSC) are selectively activated at specific distances and orientations relative to environmental boundaries and vertices, tuned by the heading directions of the animal, to perform egocentric vector coding of the environmental geometry. However, the neural circuit mechanisms explaining how egocentric representation of vertices and boundaries emerges are yet unknown. One possible

…Inhibitory interneurons play essential roles in spatial and working memory function by gating signal flow and sculpting microcircuit d

…encompassing pyramidal neurons, PV

…Parvalbumin interneurons (PVI) in the associative striatum may have a crucial role in this action plan selection despite their low numbers. Indeed, by inhibiting striatal processing, PVI may

Newly discovered group of natural antisense long non-coding RNAs, known as SINEUPs, exhibits the ability to ameliorate defective gene expression by enhancing mRNA translation. A subgroup of severe and drug resistant forms of epileptic encephalopathies (EEs) have been associated to the haploinsufficiency of the GABRA1 gene that, by coding for the α1 subunit of the main inhibitory synaptic receptor, leads to impaired GABAergic inhibition. By taking advantage of a heterozygous α1 knock-out mouse model of epilepsy (het-α1 KO), we exploit SINEUP approach to restore GABAergic inhibitory deficits. Co

In emotion research, anxiety and fear have always been interconnected, sharing overlapping brain structures and neural circuitry. Recent investigations, however, have unveiled parallel long-range projection pathways originating from the ventral hippocampus, shedding light on their distinct roles in anxiety and fear. Specifically, vCA1 projections to the lateral hypothalamus and medial prefrontal cortex are associated with anxiety-related experiences, whereas vCA1 projections to the amygdala mediate context-dependent fear. However, the precise mechanisms coordinating these parallel vCA1 project

…unclear whether distinct subtypes of interneurons make different contributions in