Topic: radial migration

The neocortex is stereotypically organized into layers of excitatory neurons arranged in a precise parallel orientation. Here we show that dynamic adhesion both preceding and following radial migration is essential for this organization. Neuronal adhesion is regulated by the Mowat-Wilson syndrome-associated transcription factor Zeb2 (Sip1/Zfhx1b) through direct repression of independent adhesion pathways controlled by Neuropilin-1 (Nrp1) and Cadherin-6 (Cdh6). We reveal that to initiate radial migration, neurons must first suppress adhesion to the extracellular matrix. Zeb2 regulates the multi

During cortical development, intrinsic and extrinsic factors regulate how radial glial cells (RGs) proliferate and produce neurons in a highly controlled manner. To date, investigation of the mechanisms regulating radial migration has predominantly relied on studies of cultured cortical slices or employed in utero electroporation strategies. However, these methods are not suitable for investigating the role of gradients of extracellular signals. To address this, we developed an innovative in vitro model where RGs processes support the migration of young pyramidal neurons generated in situ.We p