Topic: rapid eye movement sleep

Hippocampal representations that underlie spatial memory undergo continuous refinement following formation during exploration. Understanding the role of sleep in this process has been challenging because of the inaccessibility of place fields when animals are not actively exploring a maze. Here, we devised a novel Bayesian learning approach based on the spike-triggered average decoded position in ensemble recordings to track dynamically the spatial tuning of individual neurons during offline states in freely moving rats. Measuring these dynamic tunings, we found spatial representations within

Diurnal animals with monophasic sleep patterns exhibit species-specific cycles of slow-wave sleep (SWS) alternating with rapid eye movement sleep (REMS). A recent study revealed that in the diurnal reptile Pogona vitticeps, SWS and REMS regularly alternate with approximately 2-min cycles throughout the night, generating more than 300 SWS/REMS cycles. Although the cycle varies significantly across species, common neural mechanisms may be involved. However, the precise mechanisms responsible for maintaining these regular cycles remain elusive. Sleep-wake patterns are predominantly regulated by t

The circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep, and non-rapid eye movement sleep is not thoroughly understood. Sleep is thought to arise due to decreased activity in the ascending reticular arousal system, which originates in the brainstem and awakens the thalamus and cortex during wakefulness. Despite the conventional association of sleep-wake states with hippocampal rhythms, the mutual influence of the hippocampal formation in regulating vigilance states has been largely neglected. Here, we focus on the subiculum, the main outp

Postoperative delirium (POD), expressed from mild forms such as short cognitive impairments to chronic cognitive deficits or death, is relevant in up to 80% of patients after surgery under general anesthesia (GA). The systemic and mechanistic relationship between preoperative anxiety (POA) and POD is largely unknown. A preoperative anxious phenotype and the identification of sleep impairments due to it hold the strong potential to establish predictive parameters for POD. These discoveries may further elucidate the neuronal mechanisms underlying POA and POD. 37 C57BL/6N male mice (12-weeks-old)

Rapid eye movement sleep (REM) is often considered as a homogeneous state of sleep, defined by a striking resemblance of its electroencephalogram (EEG) to the one observed in wakefulness. The occurrence of transient events in REM, such as limb twitches or facial and rapid eye movements, supports the view of a paradoxical state of sleep. Here, we investigated the local activity of the primary somatosensory or barrel cortex (S1) in naturally sleeping head-fixed male mice during REM. Through local field potential (LFP) recordings, we uncovered local appearances of spindle waves in the barrel cort