Topic: RbFOX1

The splicing factor RBFOX1 exerts a pleiotropic effect on numerous psychiatric and neurodevelopmental disorders; however, the exact working mechanisms remain largely unknown. One potential mechanism that could partially explain the influence of RBFOX1 on some psychiatric traits is through the modulation of the serotonergic system, a common target for medical intervention in psychiatric disorders associated with RBFOX1.Here we studied a rbfox1 mutant zebrafish model, carrying a rbfox1sa15940 allele that expresses a shorter, aberrant rbfox1 mRNA. In the homozygous rbfox1sa15940 zebrafish we obse

Cocaine and other addictive drugs are known to cause sensitization, a reinforced behavioral response to repeated exposures to the same drug, eventually contributing to compulsive use. The sensitized response is maintained for several weeks of abstinence, and outlasts transient transcription-dependent changes in neuronal physiology and plasticity. Due to its complex properties, the 3D structure of the genome may undergo long-lasting changes upon a single drug exposure, and serve as cellular memory in the path to addiction. Here, we show that a single exposure to cocaine induces extensive rewiri