Topic: reach-to-grasp task

To understand the cortical control of complex limb movements, we must identify how movement control signals differ across different sensorimotor regions. Here we characterize the structure of movement-related activity across 6 subregions of primary and secondary motor (M1 and M2) and primary somatosensory cortex (S1) in the mouse. To evoke coordinated forelimb movements, we developed a reach-to-grasp task in which head-fixed mice performed delayed reaches to 15 distinct target locations. We performed two-photon calcium imaging in layer 2/3 of each area (>8,000 neurons, 19 sessions, 4 mice). Th

Ischemic stroke results from neural tissue death due to a decrease in blood supply, and is a major cause of death and motor disabilities worldwide. Although it is established that the tissue immediately surrounding the stroke core undergoes spontaneous functional reorganization, partially taking over lost functionality, the role of the healthy contralesional cortex remains unclear. Adaptions in neuronal activity on the contralesional side have been reported both in humans and in rodent stroke models, but it remains elusive whether such modifications represent spontaneous functional re-mapping