Topic: reactive gliosis

Despite clinical data stretching over millennia, the neurobiological basis of the effectiveness of acupuncture in central nervous system disorders has remained elusive. In this study, using an established model of acupuncture treatment in Parkinson’s disease (PD) mice, we show that peripheral acupuncture stimulation activates hypothalamic melanin-concentrating hormone (MCH) neurons via nerve conduction. Moreover, we identify two distinct neural pathways originating from anatomically and electrophysiologically distinct MCH neuronal subpopulations, projecting to the substantia nigra and hippocam

Traumatic brain injury (TBI) is a cause of disability and a risk factor for the development of epilepsy, partially mediated by reactive gliosis. The aim of this project was to observe astroglial and microglial reactions to brain injury and identify sex differences in the process of glial scar formation.Penetrating cortical brain injury was induced on postnatal day 30 (P30) in male and female rats. The animals were perfused on P32, P38, P46, or P60. Brain tissue was sectioned and stained against glial fibrillary acidic protein (GFAP, astrocyte marker) and ionized calcium-binding adapter molecul

In this study, we explored the neuroprotective properties of a novel Tat-CRYM recombinant protein, designed with a Tat domain to enhance blood-brain barrier permeability, within a transient cerebral ischemia using Mongolian gerbils. Our focus was on Ketimine reductase mu-crystallin (CRYM), a protein with widespread distribution in the brain, including areas like the cerebral cortex, corticospinal tract, and basal ganglia, and its diminished expression in neurodegenerative diseases such as Huntington's and Alzheimer's.We assessed the intracellular uptake of Tat-CRYM protein by NSC34 cells, reve