Topic: red nucleus

Spinal cord injury (SCI) is a devastating condition of the CNS for which there are no restorative therapies. Neuronal death at the primary lesion site and in remote regions that are functionally connected to it is one of the major contributors to neurological deficits induced by SCI. In this study we examined the crosstalk between mitochondria and the epigenome, defined as “mitonuclear communication” and its contribution to the remote damage-induced by SCI in the red nucleus (RN) contralateral to the injury site. Using a mouse model of SCI, we performed RNA-seq analysis on RN isolated from con

The Cerebellar Nuclei (CN) are the sole output of the cerebellum, integrating and relaying information computed in the cerebellar cortex and transmitted by Purkinje cells, before sending it to the downstream targets of the cerebellum. The cerebellum receives two types of afferents: mossy fibers (sensory-motor context) and climbing fibers (teaching signals). These inputs project to the cerebellar cortex, with some also sending direct excitatory collaterals to the CN. However, little is known about the functional properties and the impact of these excitatory inputs on the firing of cerebellar nu