Topic: reduced rank regression

Sensory neuron responses vary across repeated presentations of the same stimuli, but whether this trial-to-trial variability represents noise versus unidentified signals remains unresolved (1–3). Some of the variability can be attributed to correlations of neural activity with locomotion, arousal, and other overt movements (4–7). We hypothesized that distributed brain states, i.e., patterns of neural activity observable in other brain regions, may account for more of the unexplained trial-to-trial variability in responses of sensory cortical neurons. To test this, we used Neuropixels 2.0 probe

Spatial vision is the ability to perceive visual objects within 3-dimensional space, and its dysfunction is detrimental to our ability to interact with the visual world. Our visual experience is a result of the concerted activity of neuronal ensembles in the sensory hierarchy. How the organization of objects in space influences interactions in this hierarchy is poorly understood. We investigated this question in the inter-laminar interactions in the visual cortex, a canonical motif of hierarchical information processing. We analyzed laminar electrophysiological recordings in cortical area V1 w