Seminar · Computational Neuroscience
Restless engrams: the origin of continually reconfiguring neural representations
Timothy O'Leary · University of Cambridge
Fri, Mar 5, 2021 · 15:00 UTC
During learning, populations of neurons alter their connectivity and activity patterns, enabling the brain to construct a model of the external world. Conventional wisdom holds that the durability of a such a model is reflected in the stability of neural responses and the stability of synaptic connections that form memory engrams. However, recent experimental findings have challenged this idea, revealing that neural population activity in circuits involved in sensory perception, motor planning and spatial memory continually change over time during familiar behavioural tasks. This continual cha