Topic: relapse

Support basic, translational, clinical or population research on monosomy 7 AML and other rare, high-risk cytogenetic AML subtypes. Projects should address mechanisms, therapeutic vulnerabilities, biomarkers, treatment response, relapse or survivorship, producing useful diagnostic, therapeutic or trial-enabling findings. The three-year term begins 1 April 2027. Applications are due 1 December 2026 at 13:00 U.S. Eastern Time.

The anterior insular cortex (AIC) has been implicated in addictive behaviour, including the loss of control over drug intake, craving and the propensity to relapse. Evidence suggests that the influence of the AIC on drug-related behaviours is complex as in rats exposed to extended access to cocaine self-administration, the AIC was shown to exert a state-dependent, bidirectional influence on the development and expression of loss of control over drug intake, facilitating the latter but impairing the former. However, it is unclear whether this influence of the AIC is confined to stimulant drugs