Topic: repaglinide

High fat diet (HFD) chronic intake induces metabolic syndrome in mice, characterized by a body weight increase and insulin resistance (IR). Furthermore, non-alcoholic fatty liver disease (NAFLD) is strongly linked to metabolic syndrome appearance. Obesity is a risk factor in the development of neurodegenerative diseases, neuropsychiatric disorders and is associated with cognitive decline. DREAM/kchip3/calsenilin (DREAM) is a multifunctional protein that belongs to the neuronal Ca2+ sensor family. Previous studies have demonstrated the relevance of DREAM in nociception and in learning and memor

Aging, both physiological and pathological, results in a widespread decline in cognitive, sensory, and motor functions. Adult hippocampal neurogenesis is a phenomenon that diminishes with age across various mammalian species and has been proposed as a significant factor linked to age-related cognitive deficits. Our laboratory's preliminary studies reveal that mice lacking the DREAM protein (dream -/-) exhibit cognitive improvement with aging, along with increased neurogenesis and greater development of immature neurons positive for DCX compared to wild-type mice of the same age. To further und