Topic: Repetitive transcranial magnetic stimulation

Central post-stroke pain (CPSP) is a chronic pain resulting from cerebrovascular accidents in somatosensory pathways including thalamus, and clinical findings suggest that the mechanism involves abnormal brain activity and network reorganization due to maladaptive plasticity. Neuromodulation technique, such as repetitive transcranial magnetic stimulation (rTMS) targeting primary motor cortex (M1) have shown promise for the treatment of intractable pain, and high-frequency rTMS (Hf-rTMS) exhibits analgesic effects compared to low-frequency rTMS (Lf-rTMS), while its analgesic mechanism is unknow

Down-regulating emotional overreactions toward threats is fundamental for developing treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for top-down modulatory processes, and despite previous studies adopting repetitive Transcranial Magnetic Stimulation (rTMS) over this region provided encouraging results in enhancing extinction, no studies have hitherto explored the effects of stimulating the medial anterior PFC (aPFC, encompassing the Brodmann area 10) on threat memory and generalization. In this study, we aimed to test an rTMS procedure over the aPF

Intermittent theta burst stimulation (iTBS), a specialized protocol of repetitive transcranial magnetic stimulation (rTMS), is a non-invasive method used to study brain function in health and disease in both animal models and humans. Despite increasing interest, fundamental questions regarding the cellular and molecular effects of iTBS/rTMS on brain activity remain unanswered. It is generally recognized that c-Fos can be used as a molecular marker of neuronal activity following different types of stimuli. Therefore, this study aimed to investigate the effects of seven-day iTBS application on c

Repetitive transcranial magnetic stimulation (rTMS) is a widely used method of non-invasive brain stimulation in both research and clinical settings, aimed at inducing synaptic plasticity and targeting conditions like pharmaco-resistant depression and post-traumatic stress disorder. However, the detailed molecular mechanisms underlying rTMS-induced plasticity remain not well understood. N6-methyladenosine (m6A) is the most prevalent modification in the human transcriptome. m6A is known for its reversible nature and thus is a prime candidate for modulating synaptic plasticity via gene expressio