Topic: resting potential

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is thought to play a key role in the modulation of dendritic and somatic excitability in neurons [1]. The enigmatic HCN channel, enigmatic because of the long puzzling relation between HCN expression and neural function [1, 2, 3], has an inhomogeneous distribution along the somato-dendritic axis, where the density is higher in distal dendritic compartments [1, 4]. In this modeling project, we studied the influence of HCN channel density distribution on the attenuation of current injection from the bifurcation point of the dendri

Brains are energy-hungry and evolution has driven them to work in an energy-efficient manner. In food restriction experiments, Padamsey et al. [1] have recently observed that individual neurons trade off energy consumption and information transmission. Specifically, neurons appear to reduce energy consumption by changing their integration properties through the adaptation of membrane resistance, resting potential, and synaptic efficacies, which comes at the cost of reduced information transmission. Furthermore, they found that individual neurons assume a broad range of values of these paramete