Resting-state functional connectivity

Resting-state functional connectivity (FC) has received considerable attention in the study of brain-behavior associations. However, the low generalizability of brain-behavior studies is a common challenge due to the limited sample-to-feature ratio. In this study, we aimed to improve the generalizability of brain-behavior associations in resting-state FC by focusing on diverse and stable edges, i.e., edges that show both high between-subject and low within-subject variability. We used resting-state data from 1003 participants with multiple fMRI sessions from the Human Connectome Project to gro

…However, lower resting-state functional connectivity (rsFC) between visual and somatosensory and auditory cortical areas and weaker interhemispheric rsFC have been reported in blind humans. Moreover, rsFC is more variable in blind individuals than in sighted controls. Cross-modal recruitment of visual cortical areas has also been shown in mice. Cross-modal activation involves modifications of the excitatory/inhibitory balance, rather than establishing new c

…In the present study, we explored resting-state functional connectivity of the claustrum in relation to both habitual sleep parameters and cognitive control performance in humans. Our aim was to explore the role

…imaging data, which can be considered functional. Functional data refers to data that are inherently functions, where each observation represents a curve, or some other form of continuous variation over a domain.In this study, we propose a novel approach, the functional sequence kernel association test (fSKAT), aimed at identifying single-nucleotide polymorphisms (SNPs) associated with functional phenotypes. To address the infinite space of functional data, we employ functional princip

Functional ultrasound (fUS) imaging has recently allowed 3D functional imaging in awake mice using motorized linear or matrix arrays (Brunner et al., 2020; Bertolo et al., 2021). However, the tradeoff between the field of view and temporal resolution introduced by motorized scanning hinders acquiring whole-brain resting state Functional Connectivity (rsFC), whereas the limited sensitivity of matrix arrays prevents transcranial imaging in mice. Here we propose a new hybrid approach dedicated to 3D rsFC in the whole mouse brain with intact skull.A newly developed 15 MHz multiarray probe (IcoPrim

The adult human brain shows remarkable plasticity following perceptual learning, resulting in improved visual sensitivity. However, such improvements in visual perception commonly require extensive practice and hours of training. Therefore, an ongoing challenge has been to improve the efficiency of such prolonged repetition-based learning. Here we aimed to uncover whether improving the efficiency of repetition-based learning with brief memory reactivations engages distinct neural mechanisms. To address this question, human participants encoded a visual discrimination task. Then, three sessions

…We also assessed resting-state functional connectivity using functional magnetic resonance imaging (rs-fMRI). Ana

…of studies have tracked longitudinal resting-state functional connectivity in rodents, with these studies only using male animals. The aim of this study is to determine sex-specific developmental trajectories of brain development using functional connectivity analysis. Male and female Wistar rats were scanned at postnatal day 28, 35, 49, 70 and 91 under light sedation. Functional connectivity was measured between several regions o

…learning and processing.Whole-brain resting-state functional connectivity (FC) of bilateral hippocampi and caudate nuclei was analyzed in 117 participants with diverse multilingual language experience, to assess relationships of FC with performance on verbal declarative memory and procedural memory tasks, and

Previous research in developmental neuroscience has explored changes in the brain's functional connectivity during various developmental stages, offering insights into its dynamic network changes. However, it remains unclear how these alterations relate to cognitive performances.We employed partial least squares (PLS) to uncover the latent components (LCs) that describe the relationship between visual cognition, attentional reorientation, and executive function performances and resting-state functional connectivity (RSFC) across ages. Forty-two participants participated in fMRI sessions includ

Over the last decade, research on curiosity – the desire to seek new information – has been rapidly growing. Several studies have shown that curiosity elicits activity within the dopaminergic circuit and thereby enhances hippocampus-dependent learning. However, given this new field of research, we do not have a good understanding yet of (i) how curiosity-based learning changes across the lifespan, (ii) why some people show better learning improvements due to curiosity than others, and (iii) whether lab-based research on curiosity translates to how curiosity affects information seeking in real

Although substance use disorders (SUDs) occur commonly in patients with schizophrenia and significantly worsen their clinical course, the neurobiological basis of SUDs in schizophrenia is not well understood. Therefore, there is a critical need to understand the mechanisms underlying SUDs in schizophrenia in order to identify potential targets for therapeutic intervention. Since drug use usually begins in adolescence, it is also important to understand the long-term effects of adolescent drug exposure on schizophrenia- and reward- related behaviors and circuitry. This talk will combine pharmac