Topic: rhombic lip

Understanding the neurodevelopment of cerebellar nuclei (CN), the primary output of the cerebellum, is crucial. Traditionally, the rhombic lip (RL) and ventricular zone (VZ) have been known as the origins of glutamatergic excitatory and GABAergic inhibitory CN neurons, which emerge after embryonic day 9 (E9). However, our study uncovers a novel subset of cells in the nuclear transitory zone (NTZ), a transient area for future CN that appears even before E9. Our study’s objective is to map the fate of these early-appearing cells in the developing cerebellum. Utilizing SncaGFP transgenic mice, th

Medulloblastoma (MB) is an embryonal tumour that arises in the posterior fossa, being the most common malignant paediatric brain tumour. Currently there are four subgroups of medulloblastoma described, which arise from the alteration of specific neuronal stem or progenitor cell populations in exact spatio-temporal patterns(1). Group 4 MB (G4MB) is the most common subgroup of MB and has recently been described to arise from the failure of developmental processes in the differentiation of the rhombic lip (RL), implicating glutamatergic progenitors as putative cells of origin (2). Such cells orig