Topic: risk-taking behaviour

Stress and sleep disruption promote inflammation and metabolic adaptations, with important disease-modifying implications for psychiatric disorders. Using a novel chronic unpredictable sleep disruption (CUSD) paradigm, we characterised the impact of disrupted sleep and/or stress hormone exposure on locomotor behaviour and central markers of inflammation in the nucleus accumbens (NAc), a region implicated in regulation of mood, motivation and locomotor activity. Forty-eight Wistar rats (24 male; 24 female) were separated into groups exposed to combinations of CUSD/non-CUSD and corticosterone (2

Substance use disorders (SUD) and aggressive behaviour often co-occur within individuals, along with transdiagnostic behavioural traits such as risk-taking behaviour, impulsivity, irritability, neuroticism, or anxiety. This study investigates shared genetic risk factors across these phenotypes using public genome-wide association study (GWAS) data: five GWAS on SUD, two on aggressive behaviour, and seven on related behavioural traits. We calculated genetic correlations and identified trait-specific associated SNPs shared between these phenotypes using Polarmorphism. Also, we determined how the